3DO Games(s)
| Game | Region | Code | Type | Developer | Publisher | Release Date | Local Title | Rarity |
|---|---|---|---|---|---|---|---|---|
| Sample This! | NA | Demodisc | Crystal Dynamics | Crystal Dynamics | 1994 | 1 | ||
| Samurai Shodown | EU | Fighting | Crystal Dynamics | Crystal Dynamics | 1995 | 1 | ||
| Samurai Shodown | NA | Fighting | Crystal Dynamics | Crystal Dynamics | 1995 | 1 | ||
| Samurai Shodown | JP | FZ-SJ3155 | Fighting | Crystal Dynamics | Crystal Dynamics | 1995 | サムライ・ショーダウン | 1 |
| San Diego Zoo Presents: The Animals! | NA | Non-game, Edutainment | Arnowitz Studios | The Software Toolworks | 1993 | 1 | ||
| Sangokushi IV | JP | Turn-based strategy | Koei | Koei | March 24, 1995 | 三國志Ⅳ | 1 | |
| Scramble Cobra | EU | FZ-SE0404 | Combat flight simulation | Genki | Panasonic | 1995 | 1 | |
| Scramble Cobra | NA | FZ-SM0404 | Combat flight simulation | Genki | Panasonic | 1995 | 1 | |
| Scramble Cobra | JP | FZ-SJ0404 | Combat flight simulation | Genki | Panasonic | 1995 | スクランブル・コブラ | 1 |
| Scramble Cobra - Premium Version | JP | Combat flight simulation | Genki | Panasonic | 1995 | スクランブルコブラ プレミアムバージョン | 1 | |
| Scramble Cobra - Demo | JP | FZ-JJ9DSP-5G | Demodisc | Genki | Panasonic | 1995 | 1 | |
| Seal of the Pharaoh | NA | FZ-SM1751 | Dungeon crawl, Role-playing game | System Sacom | Panasonic | 1994 | 1 | |
| Secre: FUmin no Omocha Hako | JP | FZ-SJ2651 | Non-game | Glams Interactive Labo | Glams Interactive Labo | August 27, 1994 | セクレ・フーミンのおもちゃ箱 | 1 |
| Seimei Handan | JP | FZ-SJ4053 | Non-game | Ariadne | Ariadne | February 17, 1995 | 姓名判断 | 1 |
| Quarantine | NA | First-person shooter, Racing, Vehicular combat | Imagexcel | GameTek | 1994 | 1 |